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Clinically Relevant, Medically Actionable
GeneDose? leverages the scientific data and expertise of the 64-year-old Coriell Institute for Medical Research. Backed by CLIA-licensed laboratories and genotyping assays, GeneDose? Genetic Response Report provides physicians with recommendations that they can understand changes in doses, suggested medications by therapeutic class, and warnings. Gone are the days of trying to translate genotypes into clinically useful information; no more trial and error medication management before seeing patient improvement.
GeneDose? LIVE merges more than a dozen precision prescribing decision vectors and builds on the genetic insight the GeneDose? Genetic Response Report provides. In real-time, the visual report relays a quick summarization of which drugs present the highest degree of risk and provides physicians with a tool to virtually modify and assess the treatment plan and find the scenario that presents the least amount of risk, while still accomplishing the intended therapy.
Pharmacokinetics, the understanding of what the body does to a drug, is impacted by genetics. GeneDose? screens genes that impact the transport of drugs into the cell; transform prodrugs into their active forms; are responsible for detoxifying and excreting the drug; and are associated with a change in response to treatment.
GeneDoseTM Pharmacogenomic test and report
Genetic variation influences the way drugs are processed and utilized by the body. Pharmacogenomics is the science that explores the effects of specific genetic variants. GeneDose? tests the clinically relevant pharmacogenomic genes in a single, comprehensive test and the GeneDose? Genetic Response Report provides the detailed pharmacogenomic results and the correlative clinical effects for individuals. This insightful tool supports the physician in making scientifically reinforced treatment decisions.
For Physicians and Healthcare providers
GeneDose? Genetic Response Report and GeneDose? LIVE provides easy to understand recommendations to use directly while making medical decisions—concise and understandable without a need for a genetics background.
GeneDose? helps tune medication regimens. GeneDose? simplifies the complex issue of personalized medication management for drugs that are affected by genetic variations.
An in-depth understanding of the medication of interest along with the patient’s genetics is paramount to proper personalized medication management. It is not enough to know the metabolizer status of a patient.
A patient can be any of four metabolizer statuses for a particular metabolic enzyme (tested by screening specific places within the genome): an extensive metabolizer (normal metabolic activity); an intermediate or poor metabolizer (reduced or lacking activity); or an ultrarapid metabolizer (increased metabolic activity).
Therapeutic Classes Include:
- Pain management
- Infectious diseases